Proving the Business Case for the Internet of Things

Pfizer and IBM collaborate to tackle Parkinson’s disease

Steve Rogerson
April 19, 2016
 
Pfizer and IBM are collaborating to develop remote monitoring aimed at transforming how clinicians deliver care to patients suffering from Parkinson’s disease. The experimental approach will rely on a system of sensors, mobile devices and machine learning to provide real-time, round-the-clock disease symptom information to clinicians and researchers.
 
The goal is to obtain a better understanding of a patient’s disease progression and medication response to help inform treatment decisions and clinical trial design, while also speeding the development of new therapeutic options.
 
Parkinson’s disease in particular requires on-going adjustment to medication depending on the progression of the disease and response of the patient. The collaboration seeks to create a holistic view of a patient’s well-being by seeking to measure accurately a variety of health indicators, including motor function, dyskinesia, cognition, sleep and daily activities such as grooming, dressing and eating.
 
Insights from these data could help clinicians understand the effect of a patient’s medication as the disease progresses, enabling them to help optimise the patient’s treatment regimen as needed. Data generated through the system could also arm researchers with the insights and real-world evidence needed to help accelerate potential new and better therapies.
 
“We have an opportunity to potentially redefine how we think about patient outcomes and 24-7 monitoring, by combining Pfizer’s scientific, medical and regulatory expertise with IBM’s ability to integrate and interpret complex data in innovative ways,” said Mikael Dolsten, president of worldwide research and development for New York-based Pfizer. “The key to our success will be to deliver a reliable, scalable system of measurement and analysis that would help inform our clinical programmes across important areas of unmet medical need, potentially accelerating the drug development and regulatory approval processes and helping us to get better therapies to patients, faster.”
 
According to the World Health Organisation, neurological disorders including Parkinson’s disease, Alzheimer’s disease, stroke, multiple sclerosis and epilepsy impact almost one billion families around the world, and account for 12 per cent of total deaths globally. Many diseases of the brain, spine and nerves are progressive conditions that get worse over time and can create uncontrolled movement, impair the ability to think, and cause other debilitating symptoms impacting the patient’s quality of life.
 
Approximately 60,000 Americans are diagnosed with Parkinson’s disease each year according to the Parkinson’s Disease Foundation, and an estimated seven to ten million people suffer from the disease globally.
 
 “With the proliferation of digital health information, one area that remains elusive is the collection of real-time physiological data to support disease management,” said Arvind Krishna, senior vice president of IBM Research. “We are testing ways to create a system that passively collects data with little to no burden on the patient, and to provide doctors and researchers with objective, real-time insights that we believe could fundamentally change the way patients are monitored and treated.”
 
The two companies project that the system will move into initial clinical testing quickly. Pfizer and IBM will convene an external advisory board of patient groups, advocacy organisations, clinicians and neuroscientists for guidance on the use of technology, medical devices, data management and research protocols, and to ensure the needs of patients guide the programme.